Family doctor

DRUG NAME: omeprazole

USE: Antiulcerant

Losec is used for the treatment of stomach ulcers, gastro-oesophageal reflux disease (GORD) and Zollinger-Ellison syndrome (A rare condition with very high stomach acid). It is also prescribed for NSAID-associated (e.g. aspirin) ulceration, and during general anaesthesia to prevent acid aspiration.

This medicine is known as a proton pump inhibitor which blocks excess stomach acid production via a unique mechanism ( H+,K+-ATPase). By controlling the production of excess acid it allows the eroded lining of the stomach or oesophagus to heal due to the agent's long duration of action and high potency.

Caution:

• Gastric cancer
• Liver disease
• Pregnancy and breastfeeding

Side effects:

Rarely:

• headache, dizziness
• stomach upset/pain
• constipation
• rash
• blurred vision
• depression
• dry mouth
• muscle and joint pain

Interactions:

This medicine inhibits the metabolism of diazepam, phenytoin, warfarin (monitor).

Patient information:

• Follow instructions carefully on the label of this medicine or as directed by your doctor.
• Take this medicine regularly for it to work effectively (approximately 4 days until maximum effect).
• Avoid smoking and eating certain foods (talk to your pharmacist).
• Food: Taken after if this medicine upsets your stomach
• Alcohol: May aggravate ulcer so best avoided
• Swallow capsule whole or open capsule and mix contents with fruit juice or yoghurt.
• Contact your doctor or seek urgent medical help if side effects are severe or ongoing.